Table 3.

Gene methylation prevalence over time in plasma

Baseline6-Month12-Month24-Month48-Month
Genen (%)n (%)n (%)n (%)n (%)
CDKN2404 (25)343 (19)267 (28)207 (21)111 (15)
MGMT402 (10)342 (12)266 (8)206 (12)110 (7)
RASSF1398 (4)342 (7)265 (8)206 (11)110 (5)
DAPK1a252 (17)294 (16)246 (13)205 (10)111 (11)
GATA4a222 (38)292 (30)243 (27)197 (36)111 (27)
GATA5393 (18)338 (18)249 (14)193 (14)107 (7)
PAX5α394 (8)333 (3)261 (3)187 (3)93 (3)
PAX5β396 (5)338 (5)262 (3)195 (4)105 (6)
  • NOTE: Minor sample size differences across other genes reflect the lack of detection of an unmethylated or methylated gene product, thus leading to unknown status.

  • aSample sizes for GATA4 and DAPK1 are reduced at baseline, 6- and 12-months because these genes were added to the methylation panel 2 years after study initiation and DNA was exhausted from some plasma samples.