Table 3.

Combined effect of risk genotypes of AKT1 rs2494740, AKT1 rs2494744, and AKT1 rs2498789 and dietary alcohol intake on breast cancer risk

TotalBMI < 30 kg/m2BMI ≥ 30 kg/m2
naHRb (95% CI)PnHRb (95% CI)PnHRb (95% CI)P
Risk genotypes
0reference4,544reference1,9691.55 (1.22–1.96)<0.001
1+1.89 (0.78–4.58)0.161350.66 (0.09–4.76)0.685195.65 (2.08–15.36)<0.001
Dietary alcohol intake per day (g)
0reference2,017reference1,0871.41 (1.01–1.97)0.044
11.15 (0.92–1.42)0.2132,5621.05 (0.80–1.39)0.7099011.79 (1.30–2.47)<0.001
Risk genotypes combined with dietary alcohol intake per day
0reference2,002reference1,0781.39 (0.99–1.95)0.056
11.13 (0.91–1.41)0.2672,5571.04 (0.79–1.37)0.7889001.73 (1.25–2.40)<0.001
22.83 (1.04–7.66)0.040201.19 (0.16–8.55)0.865107.10 (2.23–22.66)<0.001
  • Abbreviations: BMI, body mass index; CI, confidence interval; HR, hazard ratio. Numbers in bold face are statistically significant.

  • aThe number of risk genotypes (AKT1 rs2494740 AA, AKT1 rs2494744 AA, and AKT1 rs2498789 GG) defined as 0 (none) and 1+ (one or more of the alleles); the number of dietary alcohol intake defined as 0 (less than 1 g per day) and 1 (1 g or more per day); the number of combined risk genotypes and dietary alcohol intake defined as 0 (none), 1 (either risk genotypes or alcohol), and 2 (both).

  • bMultivariate regression was adjusted by age, family income, family history of breast cancer, depressive symptom, dietary alcohol per day (in risk genotypes analysis), percent calories from fat, percent calories from saturated fatty acids, physical activity, smoking, BMI (in total analysis), waist-to-hip ratio, age at menarche, age at menopause, pregnancy history, history of either hysterectomy or oophorectomy, and exogenous (unopposed and opposed) estrogen use.