Table 1.

Characteristics of LSC cohort members by ethnicity

Self-identified ethnicity
VariableHispanicNHWP
N3271502
Age (years, mean ± SD)54.7 ± 8.857.7 ± 9.51.5 × 10−7a
Gender (male, %)24.522.00.34b
Current smokers (%)73.751.85.0 × 10−13b
Pack years [pys, median (Q1–Q3)]30.5 (23.0–40.2)36.0 (26.8–50.2)<0.0001c
 10–26 (%)33.021.93.8 × 10−6b
 26–37 (%)33.030.8
 37–145 (%)33.947.3
BMI (kg/m2, mean ± SD)29.1 ± 6.127.9 ± 6.00.0027a
 16–25 (%)25.134.20.0063b
 25–30 (%)40.436.0
 30–61 (%)34.629.8
Education level (%)
 Less than college53.924.22.5 × 10−26b
 Some college or above46.275.8
Ancestry component (mean ± SD)
 European ancestry0.64 ± 0.080.97 ± 0.03NCd
 Native American ancestry0.34 ± 0.080.03 ± 0.02NCd
 African ancestry0.02 ± 0.020.00 ± 0.01NCd
Promoter methylation in sputum (%)e
 P1619.420.20.77
 MGMT26.525.30.69
 RASSF1A0.40.90.41
 DAPK19.815.50.091
 GATA441.835.00.036
 GATA519.814.20.021
 PAX5α12.314.80.30
 PAX5β8.68.00.77
 SULF242.933.30.0028
 PCDH2041.834.40.022
 DAL17.86.70.49
 JPH321.322.30.72
Number of unanswered food items [median (Q1–Q3)]0 (0–3)0 (0–2)0.0064c
Total calorie intake [kcal; median (Q1–Q3)]1782.4 (1361.1–2353.5)1714.9 (1339.9–2148.9)0.067c
rs1801133 genotypef
 CC0.340.450.0069b
 CT0.510.43
 TT0.160.12
  • aStudent t test.

  • bχ2 test.

  • cWilcoxon rank sum test.

  • dNot calculated. Ancestry analysis included 307 Hispanics and 1,390 NHW.

  • eMethylation data are complete for 268 Hispanics and 1,158 NHW.

  • fCC, CT, and TT genotype of rs1801133 were coded as 0, 1, and 2 in the statistical analysis.