Table 2.

Individual nutrients associated with risk for methylation in 268 Hispanics and 1,158 NHWsa

Nutrient (U/d)OR (95% CI)bPrawPFDRMean ± SDMedian (Q1–Q3)
Vitamin B12 (μg)0.98 (0.97–0.99)0.000350.05027.17 ± 78.4310.54 (5.86–19.67)
Manganese (mg)0.89 (0.82–0.96)0.00150.0954.54 ± 2.593.94 (2.70–5.91)
Proline (g)c1.25 (1.08–1.44)0.0020.0954.89 ± 1.934.64 (3.51–5.97)
Total trans/cis trans linoleic (g)c1.18 (1.06–1.31)0.00320.0950.44 ± 0.230.39 (0.28–0.55)
Sodium (g)1.22 (1.07–1.40)0.00340.0952.19 ± 0.862.07 (1.58–2.68)
Saturated fat (g)1.19 (1.06–1.35)0.00450.09523.80 ± 10.4022.03 (16.38–29.59)
Animal fat (g)1.15 (1.04–1.27)0.00470.09535.14 ± 17.0232.72 (22.60–44.31)
Palmitic fatty acid (g)1.21 (1.06–1.38)0.00560.09913.31 ± 5.6512.41 (9.22–16.62)
Manganese without supplements (mg)0.88 (0.80–0.96)0.00640.1013.39 ± 1.583.20 (2.22–4.22)
c9, t11 conjugate diene isomer 18:2 linoleic (mg)c1.17 (1.04–1.31)0.00720.102105.85 ± 57.7696.15 (64.14–135.3)
Stearic fatty acid (g)1.17 (1.04–1.32)0.00840.1095.99 ± 2.705.58 (4.04–7.42)
Magnesium (mg)0.88 (0.80–0.97)0.0100.119345.95 ± 137.42328.79 (248.52–423.16)
Vitamin D (IU)0.91 (0.84–0.98)0.0110.120477.13 ± 373.18455.08 (154.12–623.01)
Myristic fatty acid (g)1.12 (1.02–1.22)0.0140.1361.94 ± 1.061.74 (1.17–2.48)
Palmitelaidic trans fatty acid (g)c1.18 (1.03–1.34)0.0140.1360.09 ± 0.050.08 (0.05–0.12)
Total trans (g)c1.17 (1.03–1.32)0.0160.1402.37 ± 1.182.16 (1.5–2.97)
Niacin (mg)0.96 (0.92–1.00)0.0200.14040.18 ± 36.8633.56 (21.26–46.05)
Total folate intake (μg)0.91 (0.83–0.99)0.0210.140637.34 ± 343.80603.57 (351.12–829.65)
  • aMethylation data are complete for 268 Hispanics and 1,158 NHW.

  • bUnit for calculating the OR is the difference between Q3 and Q1. Age, sex, ethnicity, smoking history (smoking status and pack years), BMI, and total calorie intake were included in the GEE models for covariate adjustment.

  • c38% study subjects have missing data for these nutrients.