Table 1.

Inhibition of oral tumorigenesis by BRB in DB[a,l]PDE-treated mice

Treatments
DB[a,l]PDEDB[a,l]PDE+BRB
Number of micea2929
Total (M + B)27 (93)b19 (66)c
Benign tumors (B)26 (90)d9 (31)e
Malignant tumors (M)15 (52)f13 (45)
  • aMice that died before the first tumor appeared in the study or did not reach histology due to cannibalism were not counted.

  • bNumber in parentheses, percentage of mice developed tumors.

  • cTumor incidence was significantly reduced compared with DBPDE treatment, P < 0.05.

  • dBenign tumors induced by DB[a,l]PD consist of papilloma and keratoacanthoma; papilloma accounted for 94.7%.

  • eTumor incidence was significantly reduced compared with DBPDE treatment, P < 0.001.

  • fMalignant tumors induced by DB[a,l]PDE consist of squamous cell carcinoma, invasive anaplastic cell carcinoma, and fibrosarcoma; squamous cell carcinoma accounted for 88.8%.