Table 4.

Multivariable adjusted associations between adiposity at age 10 and mammographic density measures stratified by age at menarchea

VPD (%)DV (cm3)NDV (cm3)
nDiff%b95% CIPcDiff%95% CIPcDiff%95% CIPc
Age at menarche < 12.81 years
 BMI at age 10−6.37−9.17, −3.50<0.001−1.63−4.03, –0.830.1906.262.61, –10.04<0.001
Age at menarche ≥ 12.81 years
 BMI at age 10−6.37−8.99, −3.67<0.001−0.32−2.40, –1.810.7657.193.57, –10.95<0.001
Age at menarche < 12.81 years
 Body size at age 10
 1–265RefRefRef
 3–466−24.36−38.06, −7.630.007−12.83−25.88, –2.520.09624.13−1.44, –56.330.066
 527−35.65−50.32, −16.670.001−6.90−24.53, –14.850.50256.9616.45, –111.570.003
 6+12−44.19−60.69, −20.770.001−17.93−38.25, –9.090.17263.038.78, –144.330.018
Age at menarche ≥ 12.81 years
 Body size at age 10
 1–293RefRefRef
 3–463−5.64−21.91, –14.010.54612.12−2.44, –28.860.10619.46−5.02, –50.240.128
 524−30.61−47.11, −8.970.0096.04−13.15, –29.480.56360.2615.33, –122.700.005
 6+15−48.55−62.85, −28.75<0.001−9.63−28.87, –14.820.40587.5626.42, –178.280.002
  • aAll models are adjusted for attained age, birth index, family history of breast cancer, and race.

  • bPercentage differences (%Diff) represents one unit change in an adiposity measure associated with one unit change in VPD, DV, or NDV.

  • cMultivariable linear regression models were used to evaluate the associations of adiposity at age 10 with mammographic density measures. The P values for body size compare each category to the reference category. The P values for BMI test for trends.