Table 3.

Associations between the HLI score and risk of breast cancer by ethnicity, and family history among women from the Women's Health Initiative Study, 1993–2016

HT useEthnicityFamily history
NeverPastCurrentWhiteBlackOtherYesNo
Continuous (per unit score)0.96 (0.93–1.00)0.96 (0.95–0.98)0.96 (0.95–0.97)0.96 (0.95–0.97)0.98 (0.95–1.00)0.96 (0.93–1.00)0.96 (0.95–0.98)0.96 (0.95–0.98)
Quintiles
 ≤9 points
  No. of cases8133057061,59915272390881
  HR (95% CI)1.001.001.001.001.001.001.001.00
 10–11 points
  No. of cases6482307821,47510779394743
  HR (95% CI)0.89 (0.81–0.99)0.80 (0.68–0.96)1.02 (0.92–1.13)0.93 (0.86–1.00)0.92 (0.72–1.18)1.03 (0.75–1.43)1.00 (0.87–1.15)0.90 (0.82–1.00)
 13–14 points
  No. of cases6592298571,54492105391730
  HR (95% CI)0.84 (0.75–0.93)0.70 (0.58–0.83)0.92 (0.83–1.02)0.83 (0.78–0.90)0.86 (0.66–1.13)1.04 (0.77–1.42)0.88 (0.76–1.02)0.84 (0.74–0.91)
 14–15 points
  No. of cases4921597161,2206283320544
  HR (95% CI)0.76 (0.68–0.86)0.57 (0.47–0.69)0.82 (0.74–0.91)0.75 (0.69–0.81)0.78 (0.57–1.06)0.84 (0.60–1.17)0.79 (0.67–0.92)0.75 (0.67–0.84)
 ≥16 points
  No. of cases3521205889364083236392
  HR (95% CI)0.66 (0.58–0.75)0.54 (0.43–0.67)0.79 (0.70–0.88)0.70 (0.64–0.76)0.74 (0.53–1.09)0.76 (0.54–1.07)0.69 (0.58–0.82)0.72 (0.63–0.81)
Ptrend<0.01<0.01<0.01<0.010.050.05<0.01<0.01
Pinteraction0.740.780.76
  • NOTE: Adjusted for age at entry, education, nonalcohol energy intake, ethnicity, age at menarche, parity, breastfeed, history of mammograms, HT status, oral contraceptive use, age at menopause, family history, and history of BBD.