Table 1A.

Upregulated proteins and associated pathways: Comparison of response to calcium and Aquamin: Proteins

Relative abundance (average 1.8 fold change or above relative to 0.15 mmol/L calcium of 3 adenomas)
Average FC (from 3 adenomas)
CalciumAquaminAquamin
Proteins(1.5 mmol/L)(0.15 mmol/L)(1.5 mmol/L)
Proteins common with all 3 Interventions; CA 1.5, AQ 0.15, & AQ 1.5 (2 common proteins)
 None significant
Proteins common with 2 Interventions; AQ 0.15 & AQ 1.5 mmol/L (1 common protein)
 Merlin (NF2)1.5 ± 0.1a1.9 ± 0.3a2.4 ± 0.7a
Proteins common with 2 Interventions; CA 1.5 & AQ 1.5 mmol/L (9 significant out of 15 common proteins)
 Keratin-10 (KRT10)2.0 ± 0.4a1.2 ± 0.25.3 ± 6.4
 Keratin-2 (KRT2)1.9 ± 0.4a1.0 ± 0.14.6 ± 5.4
 Histone H1.5 (HIST1H1B)1.9 ± 0.4a1.5 ± 0.82.8 ± 1.6
 Histone H1.3 (HIST1H1D)1.8 ± 0.4a1.5 ± 0.82.7 ± 1.5
 60S ribosomal protein L7a (RPL7A)1.8 ± 0.3a1.6 ± 0.92.3 ± 1.4
 Histone H1.0 (H1F0)1.8 ± 0.4a1.3 ± 0.62.3 ± 0.9
 Chromatin target of PRMT1 protein (CHTOP)1.9 ± 0.2a1.5 ± 0.62.1 ± 0.7
 Olfactomedin-4 (OLFM4)2.1 ± 0.6a1.0 ± 0.02.0 ± 0.6a
 Brain acid soluble protein 1 (BASP1)1.8 ± 0.70.6 ± 0.11.8 ± 0.4a
Upregulated proteins; CA 1.5 mmol/L (3 common proteins)
 None significant
Upregulated proteins; AQ 0.15 mmol/L (1 significant out of 5 common proteins)
 ATP-dependent RNA helicase (DDX52)1.6 ± 0.1a2.0 ± 0.3a1.6 ± 0.2a
Upregulated proteins; AQ 1.5 mmol/L (6 significant out of 17 common proteins)
 Keratin, type II cytoskeletal 5 (KRT5)1.5 ± 0.2a1.1 ± 0.35.8 ± 6.6
 Histone H1.2 (HIST1H1C)1.7 ± 0.3a1.5 ± 0.82.8 ± 1.7
 Histone H1.4 (HIST1H1E)1.7 ± 0.4a1.1 ± 0.42.0 ± 0.6a
 Ribonuclease P protein subunit p38 (RPP38)1.3 ± 0.1a1.7 ± 0.4a1.9 ± 0.7
 60S ribosomal protein L14 (RPL14)1.5 ± 0.1a1.4 ± 0.61.8 ± 0.8
 Fatty acid–binding protein, liver (FABP1)1.5 ± 0.2a1.1 ± 0.01.8 ± 0.4a
  • NOTE: Values represent average fold change compared with control conditions (0.15 mmol/L calcium) ± SDs. Only statistically significant proteins presented in Table 1A.

  • Supplementary Table S3 provides a comprehensive list of proteins that were upregulated by an average of 1.8-fold or greater across the three adenomas.

  • aRepresents significance in upregulation as compared with the control at P < 0.05 level.