Table 1B.

Upregulated proteins and associated pathways: Comparison of response to calcium and Aquamin: Significant pathways

Significant pathways (Reactome V63)Entities P value
Activation of DNA fragmentation factor1.4 × 10−11
Apoptosis induced DNA fragmentation1.4 × 10−11
Formation of senescence-associated heterochromatin foci3.9 × 10−11
Apoptotic execution phase1.4 × 10−8
DNA damage/telomere stress induced senescence3.0 × 10−8
Cellular senescence3.9 × 10−6
Apoptosis4.6 × 10−6
Programmed cell death5.3 × 10−6
Major pathway of rRNA processing in the nucleolus and cytosol1.5 × 10−4
rRNA processing in the nucleus and cytosol1.9 × 10−4
rRNA processing2.2 × 10−4
Cellular responses to stress2.8 × 10−4
Cellular responses to external stimuli6.3 × 10−4
Formation of the cornified envelope9.6 × 10−4
Metabolism of RNA2.8 × 10−3
Keratinization4.2 × 10−3
Type I hemidesmosome assembly0.02
RHO GTPases activate PAKs0.03