Table 1.

Prevalence of cancer associated events (CAEs) according to histological advanced features in the adenomas analyzed

Series 1 (n = 106)Series 2 (n = 95)Series 3 (n = 96)
≥2 CAEs≥2 CAEs≥2 CAEs
n (%; 95% CI)n (%; 95% CI)n (%; 95% CI)
Adenoma
 Advanced11/48 (22.9; 12.0–37.3)12/33 (36.4; 20.4–54.9)22/96 (22.9; 15.0–32.6)
 Nonadvanced1/58 (1.7; 0–9.2)3/62 (4.8; 1.0–13.5)
 Nonadjusted PP = 0.001P < 0.001P = n.a.
 Adjusted P (q-value)q = 0.01q < 0.001q = n.a.
Size
 ≥10 mm10/39 (25.6; 13.0–42.1)9/24 (37.5; 18.8–59.4)17/76 (22.4; 13.6–33.4)
 <10 mm2/67 (3.0; 0.4–10.4)6/71 (8.5; 3.2–17.5)5/20 (25.0; 8.7–49.1)
 Nonadjusted PP = 0.001P = 0.002P = 0.8
 Adjusted Pq = 0.01q = 0.008q = 0.9
Grade of dysplasia
 High3/9 (33.3; 7.5–70.1)1/3 (33.3; 0.8–90.6)10/23 (43.5; 23.2–65.5)
 Low9/97 (9.3; 4.3–16.9)14/92 (15.2; 8.6–24.2)12/73 (16.4; 8.8–27.0)
 Nonadjusted PP = 0.06P = 0.4P = 0.007
 Adjusted Pq = 0.1q = 0.5q = 0.08
Histology
 Tubular6/76 (7.9; 3.0–16.4)5/72 (6.9; 2.3–15.5)8/44 (18.2; 8.2–32.7)
 (Tubulo)villous6/30 (20.0; 7.7–38.6)10/23 (43.5; 23.2–65.5)14/52 (26.9; 15.6–41.0)
 Nonadjusted PP = 0.08P < 0.001P = 0.3
 Adjusted Pq = 0.1q < 0.001q = 0.6
  • NOTE: Statistically significant at: P < 0.05 (uncorrected P value), q < 0.05 (adjusted P = value).

  • Abbreviation: CI, confidence interval.