Table 5.

Associations between cancer-associated CpG sites and telomere length at first blood draw (N = 346)

CpGGenePathwayβ95% CIP
cg11013726PIF1Helicase0.03−0.07–0.120.56
cg17368874RECQL4Helicase0.06−0.02–0.140.14
cg04265926ACDShelterin0.05−0.10–0.190.52
cg02271180TINF2Shelterin−0.02−0.20–0.170.87
cg19944582DKC1Telomerase−0.13−0.33–0.080.23
cg25053252WRAP53Telomerase0.07−0.20–0.340.60
cg04157159BTBD12Repair0.02−0.13–0.180.76
cg04785461DCLRE1CRepair−0.01−0.12–0.100.88
cg14369264DCLRE1CRepair0.04−0.04–0.130.31
cg24866702DCLRE1CRepair0.250.08–0.41<0.01a
cg08724919DDB1Repair0.07−0.06–0.210.29
cg20772347DDB1Repair0.14−0.09–0.370.24
cg23053918DDB1Repair0.21−0.11–0.530.20
cg24840365DDB1Repair0.12−0.18–0.430.43
cg25530631DDB1Repair0.230.05–0.420.01a
cg25628257FEN1Repair0.06−0.21–0.340.65
cg14143435HMBOX1Repair−0.01−0.22–0.190.91
cg00547758MSH2Repair0.120.01–0.230.03a
cg14262432PARP3Repair0.05−0.09–0.180.49
cg14974841PARP3Repair0.12−0.16–0.400.40
cg19223675RAD51L3Repair−0.05−0.28–0.190.69
cg24955114RAD54LRepair0.10−0.22–0.420.54
cg15034464SIRT6Repair0.09−0.09–0.280.33
cg21587861BICD1Other−0.12−0.27–0.030.13
cg19739264CLPTM1LOther0.01−0.18–0.210.90
cg09776772MAD1L1Other0.00−0.08–0.090.94
cg13247668MAD1L1Other0.08−0.17–0.320.54
cg26627933MTRROther0.10−0.23–0.420.56
cg07871324MYCOther0.06−0.24–0.350.71
cg27236539RTEL1Other−0.01−0.22–0.200.96
cg15533434SIP1Other0.11−0.07–0.290.23
  • aSignificant at P < 0.05.