Table 4.

Logistic regression results stratified by time interval between blood draw and diagnosis/censoring

0–<4 years4–<8 years
Number of observations208171
CpGGenePathwayORa (95% CI)PORa (95% CI)P
cg11013726PIF1Helicase1.21 (0.73–2.02)0.461.14 (0.72–1.78)0.58
cg17368874RECQL4Helicase1.38 (0.84–2.24)0.201.67 (1.04–2.69)0.03b
cg04265926ACDShelterin1.13 (0.70–1.81)0.622.18 (1.40–3.41)<0.01b
cg02271180TINF2Shelterin1.82 (1.09–3.02)0.02b1.32 (0.84–2.06)0.22
cg19944582DKC1Telomerase1.35 (0.87–2.11)0.182.43 (1.44–4.09)<0.01b
cg25053252WRAP53Telomerase2.04 (1.27–3.28)<0.01b1.56 (0.96–2.54)0.07
cg04157159BTBD12Repair1.03 (0.62–1.70)0.911.45 (0.95–2.20)0.08
cg04785461DCLRE1CRepair0.94 (0.52–1.69)0.841.76 (1.15–2.69)0.01b
cg14369264DCLRE1CRepair1.38 (0.82–2.33)0.232.06 (1.33–3.20)<0.01b
cg24866702DCLRE1CRepair1.60 (0.94–2.72)0.082.03 (1.28–3.21)<0.01b
cg08724919DDB1Repair1.78 (1.09–2.88)0.02b1.61 (1.05–2.46)0.03b
cg20772347DDB1Repair1.87 (1.12–3.12)0.02b1.66 (1.00–2.75)0.05
cg23053918DDB1Repair2.23 (1.29–3.86)<0.01b1.32 (0.88–2.00)0.18
cg24840365DDB1Repair2.16 (1.20–3.86)0.01b1.10 (0.71–1.71)0.66
cg25530631DDB1Repair1.18 (0.78–1.78)0.431.31 (0.85–1.99)0.22
cg25628257FEN1Repair2.30 (1.31–4.02)<0.01b1.54 (0.97–2.45)0.07
cg14143435HMBOX1Repair1.47 (0.92–2.33)0.101.45 (0.93–2.25)0.10
cg00547758MSH2Repair1.39 (0.84–2.29)0.201.77 (1.12–2.81)0.01b
cg14262432PARP3Repair1.08 (0.70–1.66)0.731.37 (0.82–2.27)0.23
cg14974841PARP3Repair1.61 (1.03–2.53)0.04b1.60 (1.00–2.56)0.05b
cg19223675RAD51L3Repair1.50 (0.94–2.40)0.091.90 (1.20–3.00)0.01b
cg24955114RAD54LRepair1.44 (0.95–2.18)0.091.38 (0.80–2.40)0.25
cg15034464SIRT6Repair1.54 (0.92–2.57)0.101.50 (1.01–2.24)0.05b
cg21587861BICD1Other1.09 (0.70–1.68)0.712.03 (1.20–3.42)0.01b
cg19739264CLPTM1LOther2.09 (1.24–3.53)0.01b1.67 (1.10–2.54)0.02b
cg09776772MAD1L1Other0.54 (0.33–0.87)0.01b1.01 (0.66–1.54)0.96
cg13247668MAD1L1Other1.66 (0.99–2.77)0.051.98 (1.22–3.21)0.01b
cg26627933MTRROther1.47 (0.97–2.24)0.072.01 (1.23–3.27)0.01b
cg07871324MYCOther1.40 (0.90–2.17)0.141.20 (0.78–1.84)0.40
cg27236539RTEL1Other1.38 (0.80–2.38)0.251.61 (1.06–2.45)0.02b
cg15533434SIP1Other2.64 (1.48–4.69)<0.01b2.32 (1.34–4.04)<0.01b
  • aORs represent the increase in odds of later being diagnosed with cancer for each 1-SD increase in methylation at that CpG site (see Supplementary Table S1 for SD values).

  • bSignificant at P < 0.05; DNA methylation was standardized to SD = 1 prior to modeling.