Table 3.

Family history of diabetes and risk of colorectal cancer by subsite

NHS, having vs. no family history of diabetesHPFS, having vs. no family history of diabetes
Colon
 Cases447/1,086186/578
 Model 1a1.08 (0.97–1.21)1.12 (0.95–1.32)
 Model 2b1.07 (0.96–1.20)1.13 (0.96–1.34)
 Model 3c1.06 (0.95–1.19)1.12 (0.95–1.32)
 Model 4d1.05 (0.94–1.18)1.11 (0.94–1.31)
Proximal colon
 Cases286/65491/312
 Model 1a1.13 (0.99–1.30)1.00 (0.79–1.26)
 Model 2b1.12 (0.97–1.29)1.01 (0.80–1.27)
 Model 3c1.11 (0.97–1.28)1.00 (0.79–1.26)
 Model 4d1.10 (0.96–1.27)0.99 (0.78–1.25)
Distal colon
 Cases149/40191/244
 Model 1a1.00 (0.83–1.21)1.33 (1.04–1.69)
 Model 2b0.99 (0.82–1.19)1.34 (1.05–1.70)
 Model 3c0.98 (0.81–1.18)1.32 (1.04–1.68)
 Model 4d0.97 (0.80–1.17)1.31 (1.03–1.67)
Rectum
 Cases123/29469/176
 Model 1a1.11 (0.90–1.37)1.39 (1.05–1.83)
 Model 2b1.10 (0.89–1.36)1.40 (1.06–1.85)
 Model 3c1.09 (0.88–1.35)1.39 (1.05–1.83)
 Model 4d1.08 (0.88–1.34)1.37 (1.04–1.82)
  • aModel 1 was adjusted for age.

  • bModel 2 was further adjusted for family history of colorectal cancer, menopausal status and postmenopausal hormone use (women), physical activity, alcohol intake, smoking, aspirin use, multivitamin use, colonoscopy/sigmoidoscopy, physical examination, hypertension, hypercholesterolemia, and AHEI score.

  • cModel 3 was further adjusted for BMI.

  • dModel 4 was further adjusted for incidence of diabetes.