Table 5.

Multivariate-adjusted percentage of difference in mean levels of colorectal cancer–related biomarkers according to family history of diabetesa

NHSHPFS
Sample sizeMean (SD)% of differenceP valueP for interaction by ageSample sizeMean (SD)% of differenceP valueP for interaction by age
Insulin
 C-peptide (ng/mL, fasting)
  Total5,1391.71 (0.92)3.90.0070.362,0842.11 (1.13)4.90.040.62
  Age <60 years2,3521.65 (0.92)5.00.038202.05 (1.13)1.90.61
  Age ≥60 years2,7871.76 (0.91)2.90.111,2442.16 (1.14)6.60.03
 C-peptide (ng/mL, nonfasting)
  Total1,3852.63 (1.65)0.30.940.061,4053.24 (2.02)2.40.560.50
  Age <60 years9142.48 (1.56)9.20.096223.05 (1.96)7.40.26
  Age ≥60 years4712.91 (1.77)−12.20.047833.39 (2.05)−1.70.76
 IGF-1 (ng/mL)
  Total7,014156.91 (54.49)1.10.200.623,219139.73 (38.34)2.20.060.84
  Age <60 years4,479164.34 (54.63)1.20.291,340150.98 (38.27)2.00.24
  Age ≥60 years2,535143.79 (51.70)1.10.471,879131.71 (36.33)2.30.15
 IGFBP-1 (ng/mL)
  Total4,21233.59 (24.55)−4.90.060.442,14319.00 (15.22)−7.80.050.65
  Age <60 years2,37531.51 (24.01)−6.00.0977217.07 (15.44)−10.20.16
  Age ≥60 years1,83736.27 (24.98)−3.20.391,37120.09 (15.00)−6.30.20
 IGFBP-3 (ng/mL)
  Total7,5704,394 (933)1.80.0020.583,2193,859 (780)0.30.770.26
  Age <60 years4,8494,398 (904)1.50.031,3404,100 (743)−1.30.30
  Age ≥60 years2,7214,389 (981)2.00.051,8793,687 (760)1.40.25
Sex hormones
 E1 (pg/mL)
  Total2,90629.61 (20.70)−2.30.280.00882130.28 (9.82)−2.40.400.20
  Age <60 years1,10830.77 (21.08)−10.60.00328129.22 (9.54)2.90.55
  Age ≥60 years1,79828.90 (20.44)1.90.4954030.83 (9.92)−5.10.14
 E2 (pg/mL)
  Total3,0757.37 (5.14)−0.60.790.031,20424.03 (6.78)−4.70.020.22
  Age <60 years1,1668.11 (5.71)−7.90.0437723.35 (6.56)−7.80.04
  Age ≥60 years1,9096.92 (4.71)2.70.3182724.34 (6.86)−3.10.18
 SHBG (nmol/L)
  Total4,93481.84 (47.37)−5.7<0.0010.801,50431.04 (11.30)−5.00.020.03
  Age <60 years2,52284.00 (48.56)−5.20.0350728.16 (10.40)−11.60.003
  Age ≥60 years2,41279.58 (46.00)−6.40.00499732.51 (11.45)−1.60.56
 Testosterone (ng/dL)
  Total5,08121.27 (10.82)−0.60.710.781,532461.34 (161.55)−3.70.100.24
  Age <60 years2,30821.28 (10.49)−1.30.58518467.13 (157.00)−7.30.05
  Age ≥60 years2,77321.25 (11.09)−0.20.911,014458.38 (163.82)−1.60.57
Adipokines
 Adiponectin (ng/mL)
  Total9,21410,906 (4,505)−4.3<0.0010.093,4617,188 (3,764)−3.90.040.12
  Age <60 years5,22110,446 (4,323)−5.7<0.0011,2716,344 (2,975)−8.70.002
  Age ≥60 years3,99311,508 (4,666)−2.50.082,1907,678 (4,075)−1.10.66
 HMW-adiponectin (ng/mL)
  Total3,5126,146 (3,748)−7.10.0020.112842,319 (1,356)−16.20.020.37
  Age <60 years1,9975,832 (3,679)−9.10.0031241,877 (1,186)−23.50.03
  Age ≥60 years1,5156,559 (3,799)−3.60.291602,661 (1,383)−10.80.25
 Leptin (pg/mL)
  Total3,76725.90 (16.42)1.40.490.882,4368.47 (6.15)9.00.0060.34
  Age <60 years2,43025.80 (16.27)1.20.649638.31 (6.14)9.80.06
  Age ≥60 years1,33726.08 (16.68)2.30.501,4738.57 (6.15)7.80.06
 Leptin sR (ng/mL)
  Total3,11930.62 (8.97)−1.50.130.021,51327.54 (7.51)−1.00.530.50
  Age <60 years2,00129.87 (8.84)0.70.5859427.43 (7.57)0.30.89
  Age ≥60 years1,11831.96 (9.04)−4.50.00591927.61 (7.48)−1.70.39
Inflammation
 CRP (mg/L)
  Total9,3923.03 (3.99)5.00.040.385,0851.69 (1.96)0.20.960.70
  Age <60 years5,1912.81 (3.75)5.80.081,9311.46 (1.84)−0.50.93
  Age ≥60 years4,2013.30 (4.24)3.60.313,1541.83 (2.02)0.90.82
 IL6 (pg/mL)
  Total6,0391.51 (1.32)−0.90.610.182,8241.34 (0.93)1.90.450.91
  Age <60 years3,4551.42 (1.29)−2.20.351,1791.10 (0.81)0.60.87
  Age ≥60 years2,5841.63 (1.35)0.70.811,6451.50 (0.97)2.30.48
 TNFR2 (pg/mL)
  Total7,0092,616 (718)0.30.730.832,8322,601 (689)−0.60.560.52
  Age <60 years3,8232,485 (671)0.80.451,0962,357 (559)−0.20.89
  Age ≥60 years3,1862,774 (740)−0.50.661,7362,755 (719)−0.70.60
  • aExcluding participants with cancer or diabetes prior to or at the year of blood draw. Biomarker levels were corrected for batch-to-batch variation using the average batch method. Model was adjusted for case–control status, fasting status (except for C-peptide), age, menopausal status and postmenopausal hormone use (women only), smoking pack-years, physical activity, and BMI.