Family history of diabetes and risk of colorectal cancer
| NHS, having vs. no family history of diabetes | HPFS, having vs. no family history of diabetes | |
|---|---|---|
| Cases | 570/1,380 | 300/873 |
| Person-years | 679,947/1,918,690 | 208,774/774,590 |
| Model 1a | 1.09 (0.99–1.20) | 1.20 (1.05–1.36) |
| Model 2b | 1.08 (0.98–1.19) | 1.22 (1.07–1.39) |
| Model 3c | 1.07 (0.97–1.18) | 1.20 (1.05–1.37) |
| Model 4d | 1.06 (0.96–1.17) | 1.19 (1.04–1.36) |
↵aModel 1 was adjusted for age.
↵bModel 2 was further adjusted for family history of colorectal cancer, menopausal status and postmenopausal hormone use (women), physical activity, alcohol intake, smoking, aspirin use, multivitamin use, colonoscopy/sigmoidoscopy, physical examination, hypertension, hypercholesterolemia, and AHEI score.
↵cModel 3 was further adjusted for BMI.
↵dModel 4 was further adjusted for incidence of diabetes.