Table 2.

Family history of diabetes and risk of colorectal cancer

NHS, having vs. no family history of diabetesHPFS, having vs. no family history of diabetes
Cases570/1,380300/873
Person-years679,947/1,918,690208,774/774,590
Model 1a1.09 (0.99–1.20)1.20 (1.05–1.36)
Model 2b1.08 (0.98–1.19)1.22 (1.07–1.39)
Model 3c1.07 (0.97–1.18)1.20 (1.05–1.37)
Model 4d1.06 (0.96–1.17)1.19 (1.04–1.36)
  • aModel 1 was adjusted for age.

  • bModel 2 was further adjusted for family history of colorectal cancer, menopausal status and postmenopausal hormone use (women), physical activity, alcohol intake, smoking, aspirin use, multivitamin use, colonoscopy/sigmoidoscopy, physical examination, hypertension, hypercholesterolemia, and AHEI score.

  • cModel 3 was further adjusted for BMI.

  • dModel 4 was further adjusted for incidence of diabetes.