Table 4.

Family history of diabetes and colorectal cancer risk by various characteristics of participantsa

NHSHPFS
CharacteristicsN, casesHaving vs. no family history of diabetesP for interactionN, casesHaving vs. no family history of diabetesP for interaction
Age0.220.05
 <60 years4121.23 (0.99–1.54)1521.65 (1.15–2.38)
 ≥60 years1,5381.02 (0.91–1.14)10211.13 (0.98–1.31)
Menopausal status0.29
 Premenopausal911.27 (0.79–2.04)
 Postmenopausal1,8591.05 (0.95–1.16)
BMI0.800.88
 BMI <25 kg/m28651.08 (0.93–1.26)4381.20 (0.96–1.51)
 BMI ≥25 kg/m21,0851.05 (0.92–1.19)7351.18 (1.00–1.40)
Smoking status0.850.93
 Never7771.10 (0.94–1.28)3621.14 (0.90–1.45)
 Ever1,1621.05 (0.92–1.19)6671.13 (0.94–1.35)
Physical activity0.250.36
 Below median1,0981.02 (0.89–1.16)6471.28 (1.07–1.53)
 Above median8521.12 (0.96–1.30)5261.09 (0.89–1.34)
Alcohol intake0.730.38
 Nondrinker8281.07 (0.93–1.25)2801.04 (0.79–1.37)
 Drinker1,1221.04 (0.91–1.19)8931.23 (1.06–1.44)
Diabetes0.280.65
 No1,8031.08 (0.97–1.20)1,0751.20 (1.04–1.38)
 Yes1470.89 (0.64–1.23)981.26 (0.84–1.90)
  • aModel adjustment was the same as model 4, Table 2.