Table 3.

Proportional differences in pIKKα/β, TLR4, and TLR5 expression in the full length of crypts and stroma, by categories of baseline participant characteristics (n = 105)a

pIKKα/β (OD), cryptsTLR4 (OD), cryptsTLR4 (OD), stromaTLR5 (OD), cryptsTLR5 (OD), stroma
Baseline characteristicN%DiffbP%DiffbP%DiffbP%DiffbP%DiffbP
Age(tertiles), years
 <5533Ref.Ref.Ref.Ref.Ref.
 55–633511.412.4−11.69.726.8
 ≥6337−13.70.48−2.10.9515.10.973.90.864.50.80
Sex
 Men49Ref.Ref.Ref.Ref.Ref.
 Women56−24.60.09−30.20.07−13.10.58−7.90.78−14.10.57
Regular NSAID use (≥1/wk)
 No73Ref.Ref.Ref.Ref.Ref.
 Yes32−10.90.49−4.50.76−5.80.76−7.00.74−14.30.44
Regular aspirin use (≥1/wk)
 No60Ref.Ref.Ref.Ref.Ref.
 Yes4520.30.2211.80.43−26.70.089.480.66−3.80.84
Smoking status
 Never61Ref.Ref.Ref.Ref.Ref.
 Former36−27.3−31.4−23.1−38.4−13.3
 Current8−15.20.15−10.10.10−22.60.0635.70.5926.30.89
BMI, kg/m2
 Normal (<25)22Ref.Ref.Ref.Ref.Ref.
 Overweight (25–30)43−1.110.575.823.633.2
 Obese (≥30)4035.70.0426.60.2152.90.5754.80.144.00.52
Had sessile serrated adenomas
 No79Ref.Ref.Ref.Ref.Ref.
 Yes2625.20.1933.50.0725.50.2694.90.0049.00.06
Red/processed meat, svgs/d
 <0.537Ref.Ref.Ref.Ref.Ref.
 0.5–130−8.4−17.1−8.28.80.1
 ≥13846.20.05−5.10.76−19.90.324.40.87−12.60.57
MIB-1 (full-length crypts)c,d
 Low33Ref.Ref.Ref.
 Medium3527.9−0.721.8
 High3520.80.3223.10.299.90.68
pIKKα/β (full-length crypts)c
 Low34Ref.Ref.
 Medium3738.325.1
 High3467.90.000457.00.05
  • Abbreviations: %Diff, proportional difference; d, day; OD, optical density; svgs, servings; wk, week.

  • aMultivariable-adjusted means, mean differences, and P values calculated using general linear models (implemented using PROC GLM in SAS 9.4), controlling for age (continuous), sex (by study arm), study center, and staining batch number, where appropriate; presented in Supplementary Table S5.

  • bProportional difference = [(comparison mean – reference mean)/reference mean] × 100%; mean presented in Supplementary Table S5.

  • cTertiles of staining batch-standardized optical density values.

  • dMissing data on 2 patients.