Table 3.

Stratified analysis on the association between DNA methylation status and precancerous gastric lesions by H. pylori infection

H. pylori negativeH. pylori positive
SG/CAGIM/Ind DYS/DYSORa (95% CI)SG/CAGIM/Ind DYS/DYSORa (95% CI)Pbheterogeneity
PCDH7c0.2
 Hypo94 (78.3)54 (75.0)1.0092 (39.0)133 (41.7)1.00
 Hyper26 (21.7)18 (25.0)1.76 (0.81–3.82)144 (61.0)186 (58.3)0.95 (0.67–1.36)
PCDH10c0.9
 Hypo71 (64.0)35 (48.6)1.00122 (56.2)127 (40.8)1.00
 Hyper40 (36.0)37 (51.4)2.34 (1.15–4.78)95 (43.8)184 (59.2)1.81 (1.26–2.61)
PCDH17c0.3
 Hypo65 (67.0)13 (31.0)1.00107 (60.5)97 (39.1)1.00
 Hyper32 (33.0)29 (69.0)4.27 (1.85–9.83)70 (39.5)151 (60.9)2.61 (1.73–3.94)
PCDH20c0.6
 Hypo70 (63.1)59 (72.8)1.0094 (45.0)120 (42.0)1.00
 Hyper41 (36.9)22 (27.2)0.90 (0.44–1.84)115 (55.0)166 (58.0)1.15 (0.79–1.67)
  • Abbreviations: Hyper, hypermethylated; hypo, hypomethylated.

  • aUnconditional logistic regression analysis, adjusting for age, gender, drinking, and smoking status.

  • bP value for heterogeneity was evaluated using Q statistics.

  • CHypo and hypermethylation for each gene was classified based on the median of methylation levels in all subjects, which was 5.71% for PCDH7, 43.89% for PCDH10, 7.40% for PCDH17, and 7.12% for PCDH20.