Table 1.

Age- and sex-specific c-statistics of two colon cancer risk prediction models in the NHS and the HPFS: one with simplified categorized predicting variables and the other with continuous predicting variables

CategoricalContinuousDifferencea
Age groupNumber of casesAUCSEAUCSEAUCSEP
Women in the NHS
<50190.6330.0630.6460.063−0.0130.0310.69
50–54470.6190.0410.5940.0410.0240.0200.23
55–59790.6350.0310.6610.030−0.0260.0160.10
60–641630.5980.0220.6080.022−0.0100.0110.40
65–691690.6400.0210.6330.0210.0060.0110.57
70–741670.5770.0220.6030.022−0.0260.0120.03
≥751720.5510.0220.5620.022−0.0110.0110.34
Age-adjusted8160.6000.0100.6090.010−0.0090.0050.07
Men in the HPFS
<50150.6000.0730.6260.072−0.0260.0310.40
50–54190.7340.0570.6990.0590.0360.0260.17
55–59370.6730.0440.6570.0440.0170.0200.40
60–64740.6190.0320.6260.032−0.0060.0150.67
65–69900.5800.0300.5850.030−0.0050.0140.69
70–74920.6190.0290.6070.0290.0120.0140.36
≥75850.6180.0300.6160.0300.0020.0130.91
Age-adjusted4120.6220.0140.6180.0140.0030.0060.60
  • Abbreviations: AUC, area under the curve; SE, standard error.

  • aContinuous as a reference model.