Table 2.

The association between genotypes of MAVS and TRAF3 and cervical precancerous lesions

Gene nameSNPGenotypeCases N (%)Controls N (%)Crude OR (95% CI)PAdjusted OR (95% CI)Pa
MAVSrs3746660CC102 (62.2)266 (62.3)11
TC59 (36.0)138 (32.3)1.12 (0.76–1.63)0.5761.13 (0.77–1.66)0.528
TT3 (1.8)23 (5.4)0.34 (0.10–1.16)0.0840.33 (0.10–1.12)0.075
DominantTC+TT62 (37.8)161 (37.7)1.00 (0.69–1.46)0.9821.01 (0.69–1.47)0.958
RecessiveCC+TC161 (98.2)404 (94.6)11
TT3 (1.8)23 (5.4)0.33 (0.10–1.11)0.0720.32 (0.09–1.07)0.063
rs6052130CC80 (48.8)248 (57.9)11
CA74 (45.1)157 (36.7)1.46 (1.01–2.12)0.0471.48 (1.02–2.16)0.041
AA10 (6.1)23 (5.4)1.35 (0.62–2.95)0.4561.40 (0.64–3.09)0.402
DominantCA+AA84 (51.2)180 (42.1)1.45 (1.01–2.08)0.0451.47 (1.02–2.12)0.038
RecessiveCC+CA154 (93.9)405 (94.6)11
AA10 (6.1)23 (5.4)1.14 (0.53–2.46)0.7311.18 (0.55–2.55)0.673
rs6116065AA77 (47.2)196 (45.9)11
GA68 (41.7)194 (45.4)0.89 (0.61–1.31)0.5580.92 (0.63–1.36)0.685
GG18 (11.0)37 (8.7)1.24 (0.67–2.31)0.5001.35 (0.72–2.55)0.353
DominantGA+GG86 (52.8)231 (54.1)0.95 (0.66–1.36)0.7710.99 (0.69–1.42)0.946
RecessiveAA+GA145 (89.0)390 (91.3)11
GG18 (11.0)37 (8.7)1.31 (0.72–2.37)0.3751.41 (0.77–2.57)0.271
rs8116776TT67 (40.9)186 (43.5)11
TC76 (46.3)202 (47.2)1.04 (0.71–1.53)0.8241.04 (0.71–1.53)0.842
CC21 (12.8)40 (9.3)1.46 (0.80–2.65)0.2171.56 (0.85–2.88)0.154
DominantTC+CC97 (59.1)242 (56.5)1.11 (0.77–1.60)0.5671.12 (0.77–1.62)0.551
RecessiveTT+TC143 (87.2)388 (90.7)11
CC21 (12.8)40 (9.3)1.42 (0.81–2.50)0.2171.53 (0.86–2.72)0.149
rs914294GG108 (65.9)275 (64.3)11
GA51 (31.1)136 (31.8)0.96 (0.65–1.41)0.8170.98 (0.66–1.45)0.907
AA5 (3.0)17 (4.0)0.75 (0.27–2.08)0.5790.75 (0.27–2.11)0.590
DominantGA+AA56 (34.1)153 (35.7)0.93 (0.64–1.36)0.7150.95 (0.65–1.40)0.799
RecessiveGG+GA159 (97.0)411 (96.0)11
AA5 (3.0)17 (4.0)0.76 (0.28–2.10)0.5960.76 (0.27–2.11)0.598
TRAF3rs12435483CC80 (48.8)170 (39.7)11
TC65 (39.6)206 (48.1)0.67 (0.46–0.99)0.0420.67 (0.45–0.98)0.041
TT19 (11.6)52 (12.1)0.78 (0.43–1.40)0.4000.76 (0.42–1.38)0.366
DominantTC+TT84 (51.2)258 (60.3)0.69 (0.48–0.99)0.0460.69 (0.48–0.99)0.044
RecessiveCC+TC145 (88.4)376 (87.9)11
TT19 (11.6)52 (12.1)0.95 (0.54–1.66)0.8500.93 (0.53–1.64)0.806
rs7156191GG60 (36.6)161 (37.6)11
CG70 (42.7)198 (46.3)0.95 (0.63–1.42)0.7980.96 (0.64–1.44)0.851
CC34 (20.7)69 (16.1)1.32 (0.80–2.19)0.2801.32 (0.79–2.20)0.284
DominantCG+CC104 (63.4)267 (62.4)1.05 (0.72–1.52)0.8161.06 (0.73–1.54)0.776
RecessiveGG+CG130 (79.3)359 (83.9)11
CC34 (20.7)69 (16.1)1.36 (0.86–2.15)0.1871.35 (0.85–2.14)0.202
rs8022180AA47 (28.7)139 (32.5)11
GA72 (43.9)195 (45.6)1.09 (0.71–1.67)0.6861.12 (0.73–1.73)0.594
GG45 (27.4)94 (22.0)1.42 (0.87–2.30)0.1601.40 (0.86–2.28)0.178
DominantGA+GG117 (71.3)289 (67.5)1.20 (0.81–1.78)0.3711.22 (0.82–1.81)0.334
RecessiveAA+GA119 (72.6)334 (78.0)11
GG45 (27.4)94 (22.0)1.34 (0.89–2.03)0.1601.31 (0.86–1.98)0.209
  • NOTE: Bold values are statistically significant.

  • aAdjusted for age (<42 and ≥42 years), passive smoking, BMI, and the initial pregnancy of age (<24 and ≥24 years).