Table 3.

Association of breast white adipose tissue inflammation with chemotherapy, smoking, ALT, and AST, adjusting for BMI

UnadjustedAdjusted for BMIc
OR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)P
Presence of CLS-BaCLS-B present vs. absentCLS-B present vs. absent
Neoadjuvant chemotherapy received
 Yes vs. no4.4 (1.4–16.9)0.024.3 (1.2–18.3)0.03
Severity of breast white adipose tissue inflammationbSevere vs. no inflammationMild vs. no inflammationSevere vs. no inflammationMild vs. no inflammation
Country of origin
 Dominican Republic vs. other Hispanic0.9 (0.2–3.8)0.851.0 (0.3–3.3)0.960.6 (0.1–3.1)0.570.8 (0.2–3.0)0.74
 Puerto Rican vs. other Hispanic5.9 (1.1–32.0)0.040.9 (0.1–6.2)0.905.0 (0.9–28.8)0.070.8 (0.1–6.1)0.83
Current smoking
 Smoker vs. nonsmoker1.3 (0.1–15.1)0.847.3 (1.3–42.1)0.031.3 (0.1–16.4)0.846.4 (1.0–39.2)0.04
Neoadjuvant chemotherapy received
 Yes vs. no4.4 (1.0–18.9)0.044.3 (1.1–17.3)0.045.2 (1.1–25.7)0.043.8 (0.9–16.2)0.07
ALT
 Per 1 interquartile range increase2.1 (1.1–4.0)0.020.9 (0.4–1.9)0.782.0 (1.1–3.9)0.030.8 (0.3–1.7)0.52
AST
 Per 1 interquartile range increase1.6 (1.0–2.8)0.070.8 (0.4–1.6)0.471.5 (0.9–2.7)0.120.7 (0.3–1.5)0.39
  • Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase.

  • aPresence of CLS-B was analyzed using logistic regression with “CLS-B absent” as the referent.

  • bSeverity of breast white adipose tissue inflammation was a 3-level categorical variable, and was analyzed using multinomial logistic regression with “no inflammation” as the referent group.

  • cBMI was analyzed as a categorical variable (<25 kg/m2, 25–29.9 kg/m2, 30–34.9 kg/m2, and 35+ kg/m2).