Table 3.

Results for gene-environment interaction analysis for each candidate SNP and high-risk HPV infection

Interaction groupDeviation from additive modelDeviation from multiplicative model
GeneRERI (95% CI)PaAP (95% CI)PaS (95% CI)PaPa
1rs3746660* high-risk HPV infection−0.52 (−3.59–2.55)0.741−0.09 (−0.62–0.45)0.7490.91 (0.51–1.62)0.7380.623
2rs6052130* high-risk HPV infection3.10 (0.02–6.18)0.0480.42 (0.13–0.71)0.0051.93 (1.03–3.61)0.0410.187
3rs6116065* high-risk HPV infection−0.14 (−2.79–2.51)0.919−0.03 (−0.53–0.47)0.9190.97 (0.53–1.76)0.9180.891
4rs8116776* high-risk HPV infection0.67 (−2.36–3.70)0.6660.10 (−0.34–0.53)0.6561.13 (0.64–2.00)0.6750.935
5rs914294* high-risk HPV infection−2.66 (−6.37–1.06)0.161−0.47 (−1.19–0.26)0.2060.64 (0.36–1.14)0.1310.079
6rs7156191* high-risk HPV infection−0.40 (−3.67–2.87)0.809−0.06 (−0.58–0.45)0.8100.93 (0.53–1.64)0.8040.655
7rs8022180* high-risk HPV infection0.79 (−2.22–3.80)0.6060.12 (−0.33–0.58)0.5991.17 (0.62–2.20)0.6270.915
8rs12435483* high-risk HPV infection−0.27 (−2.46–1.91)0.806−0.07 (−0.61–0.47)0.8070.92 (0.48–1.77)0.8010.450
  • NOTE: Bold values are statistically significant.

  • aAdjusted for age (<42 and ≥42 years), passive smoking, BMI, and the initial pregnancy of age (<24 and ≥24 years).