Table 6.

Genome-wide meta-analysis of overall test and/or interaction test with the stratified analysis for the association with HOMA-IR and multiple Cox regression for the genotypes of DOCK1 rs113847670 for predicting breast cancer risk, stratified by percentage of calories from SFA

% Calories from SFA < 7.0 %% Calories from SFA ≥ 7.0 %
Interaction test for SFA(n = 1,010)(n = 10,099)
SNPGenetic modelAllelea (Ref/Alt)PQORbPbQbHRc (95% CI)PORbPbQbHRc (95% CI)P
DOCK1 rs113847670GenotypicCC1.03E−051.0009.182.85E−080.571Reference0.990.9870.325Reference
CT0.50 (0.12–2.08)0.3411.22 (0.89–1.67)0.209
TTN/AN/A5.37 (1.33–21.63)0.018
RecessiveCC + CT/TTN/AN/A5.28 (1.31–21.30)0.019
  • NOTE: Only SNPs that are significantly genome-wide associated with HOMA-IR in overall/interaction (G*E or subgroup) analysis and breast cancer were included. Numbers in bold face are statistically significant.

  • Abbreviations: Alt, alternative allele; N/A, not available; Q, Cochran's Q; Ref, reference allele.

  • aAdditive genetic model regressed in genome-wide meta-analysis.

  • bResults from genome-wide meta-analysis of interaction test for the association with HOMA-IR.

  • cHR adjusted by age, education, annual family income, family history of breast cancer, depressive symptom, smoking, physical activity, dietary alcohol in g/day, BMI, waist-to-hip ratio, hysterectomy ever, ages at menarche and menopause, oral contraceptive use, exogenous estrogen–only use, and exogenous estrogen plus progestin use.