Table 2.

The finasteride effect on high-grade prostate cancer and low-grade prostate cancer estimated by univariate case-only methods and stratified by rs472402

GenotypeTreatment effect (RR comparing finasteride with placebo; 95% CI)P value for case-only interaction
High-grade cancerAll high grade1.22 (0.97–1.52)0.00008
CC (n = 69)1.87 (1.14–3.08)
CG (n = 169)1.52 (1.11–2.07)
GG (n = 68)0.45 (0.27–0.75)
Low-grade cancerAll low grade0.57 (0.50–0.66)0.08
CC (n = 223)0.47 (0.36–0.63)
CG (n = 444)0.57 (0.48–0.71)
GG (n = 184)0.69 (0.51–0.92)