Table 2.

Distribution of histology and presence of E6 oncoprotein in HPV16/18 DNA–positive women (E6 protein/DNA, %)

Normal/CIN1CIN2/3SCC/ADCTotal
HPV16 (E6 protein/DNA, %)11/75 (14.7)85/166 (51.2)335/380 (88.2)431/621 (69.4)
 Single HPV16 infections6/42 (14.3)51/100 (51.0)260/282 (92.2)317/424 (74.8)
 Multiple HPV16 infections5/33 (15.2)34/66 (51.5)75/98 (76.5)114/197 (57.9)
 HPV16 & 180/5 (0.0)0/3 (0.0)12/20 (60.0)12/28 (42.9)
 HPV16 & 522/9 (22.2)7/14 (50.0)15/16 (93.8)24/39 (61.5)
 HPV16 & 59/56/660/10 (0.0)14/21 (66.7)17/23 (73.9)31/54 (57.4)
 HPV16 & 511/8 (12.5)4/5 (80.0)7/8 (87.5)12/21 (57.1)
 HPV16 & 33/582/11 (18.2)8/21 (38.1)22/28 (78.6)32/60 (53.3)
 HPV16 & 39/68/351/13 (7.7)9/15 (60.0)11/14 (78.6)21/42 (50.0)
 HPV16 & 310/6 (0.0)4/7 (57.1)9/13 (69.2)13/26 (50.0)
 HPV16 & 450/4 (0.0)0/2 (0.0)1/4 (25.0)1/10 (10.0)
HPV18 (E6 protein/DNA, %)9/26 (34.6)3/6 (50.0)49/62 (79.0)61/94 (64.9)
 Single HPV18 infections3/9 (33.3)1/2(50.0)31/33 (93.9)35/44 (79.5)
 Multiple HPV18 infections6/17 (35.3)2/4 (50.0)18/29 (62.1)26/50 (52.0)
 HPV16 & 181/5 (20.0)1/3 (50.0)10/20 (50.0)12/28 (42.9)
 HPV18 & 522/2 (100.0)1/1 (100.0)1/3 (33.3)4/6 (66.7)
 HPV18 & 59/56/663/7 (42.9)0/0 (0.0)3/5 (60.0)6/12 (60.0)
 HPV18 & 312/3 (66.7)0/0 (0.0)1/2 (50.0)3/5 (60.0)
 HPV18 & 39/68/351/6 (16.7)0/0 (0.0)4/4 (100.0)5/10 (50.0)
 HPV18 & 450/0 (0.0)0/0 (0.0)1/2 (50.0)1/2 (50.0)
 HPV18 & 33/583/6 (50.0)0/0 (0.0)1/3 (33.3)4/9 (44.4)
 HPV18 & 510/4 (0.0)0/0 (0.0)1/2 (50.0)1/6 (16.7)