Table 3.

Characteristics, univariate case-only interactions, and case–control interactions of the top 10 SNPs ranked by the variable importance measure from case-only (high-grade prostate cancer cases) random forests analysis

SNP IDGeneMinor allele frequencyGenotypeP value for HWECase-only treatment RR estimateCase-only interaction P valueCase–control interaction P value
rs472402SRD5A10.48CC0.551.87 (1.14–3.08)0.000080.0019
CG1.52 (1.11–2.07)
GG0.45 (0.27–0.75)
rs11689432PER20.45GG0.021.80 (1.19–2.72)0.00030.0097
AG1.44 (0.98–2.13)
AA0.46 (0.26–0.81)
rs1052536LIG30.44CC0.941.60 (1.05–2.44)0.00170.0099
CT1.42 (1.03–1.96)
TT0.47 (0.27–0.83)
rs3756423SRD5A10.20TT0.901.71 (1.28–2.28)0.0020.0041
TG0.63 (0.43–0.94)
GG2.50 (0.48–12.87)
rs12795870Intergenic between RASSF10 and ARNTL0.067TT0.161.36 (1.07–1.73)0.040.0612
CT0.43 (0.21–0.91)
CC
rs3736544CLOCK0.36GG0.791.30 (0.91–1.86)0.090.1149
GA1.46 (1.04–2.04)
AA0.56 (0.30–1.05)
rs248797SRD5A10.50CC0.780.66 (0.42–1.04)0.0030.0352
CT1.41 (1.03–1.93)
TT1.79 (1.09–2.95)
  • Abbreviation: HWE, Hardy–Weinberg equilibrium.