Table 3.

Toxicity by treatment arm

Vitamin D (n = 102)Placebo (n = 102)
GradeaGradea
Adverse events01230123
Abdominal distension101100102000
Abdominal pain9732099300
Alkaline phosphatase increased101100102000
Anorexia101100102000
Bilirubin increased102000101010
Bloating102000100110
Breast pain102000100110
Constipation95610101100
Dizziness101100102000
Dry mouth102000101100
Dry skin102000101100
Dyspepsia102000100200
Fatigue101100102000
Flatulence102000100110
GI disorders (unspecified)102000101010
Headache100011102000
Hot flashes102000101010
Hypercalcemia102100102000
Hypercalciuria100110101100
Hypertension102000100110
Insomnia101010102000
Nail ridging101100102000
Nausea9930098400
Pain in extremity101100101100
Palpitations101100102000
Vomiting101100101100
Weight loss102000101100
Maximum grade, any adverse event761961841260
  • aNo grade 4 or 5 adverse events were reported.