Table 1.

Characteristics of HRIs tested for BRCA1 and BRCA2 mutations

Total (83; n, %)BRCA positive (48; n, %)BRCA negative (35; n, %)P
Age at first surveillance
 45–4924 (29)10 (21)14 (40)0.15
 50–5939 (47)26 (54)13 (37)
 60–6920 (24)12 (25)8 (23)
 Median age (range)54 (45–69)55 (45–67)53 (45–69)
Sex
 Male21 (25)16 (33)5 (14)0.05
 Female62 (75)32 (67)30 (86)
Race
 White77 (93)46 (96)31 (89)0.23
 African American, Other6 (7)2 (4)4 (11)
Ethnicity
 Non-Hispanic80 (96)48 (100)32 (91)0.04
 Hispanic3 (4)03 (9)
Ancestrya
 ≥2 Ashkenazi Jewish grandparents45 (54)31 (65)14 (40)0.03
 No Ashkenazi Jewish grandparents38 (46)17 (35)21 (60)
Years of education
 High school or less4 (5)2 (4)2 (6)0.93
 College23 (28)13 (27)10 (29)
 Graduate school56 (67)33 (69)23 (66)
Smoking
 Never54 (65)34 (71)20 (57)0.20
 Past or current29 (35)14 (29)15 (43)
BMI
 Normal or underweight (<25)57 (69)30 (63)27 (77)0.16
 Overweight or obese (≥25)26 (31)18 (38)8 (23)
Diabetes
 No78 (94)46 (96)32 (91)0.40
 Yes5 (6)2 (4)3 (9)
Personal history of cancer
 None44 (53)22 (46)22 (63)0.12
 ≥1 diagnosis39 (47)26 (54)13 (37)
Family history of PDAC
 ≥2 FDR17 (20)6 (13)11 (31)<0.0001
 1 FDR and ≥1 SDR30 (36)10 (21)20 (57)
 1 FDR onlyb36 (43)32 (67)4 (11)
BRCA mutation status
BRCA positive48 (58)48 (100)NANA
BRCA118 (22)18 (38)NA
BRCA230 (36)38 (62)NA
BRCA1/2 negative35 (42)NA35 (100)
  • Abbreviation: NA, not applicable.

  • aThere were no HRIs with only 1 Ashkenazi Jewish grandparent.

  • bIncludes 1 HRI whose FDR had early-onset PDAC, and 3 HRIs with 1 affected FDR and an additional affected relative (not SDR).