Table 4.

Multivariate analysis assessing factors related to methylation high in the gastric mucosa with adjustment for the presence of atrophic gastritis and intestinal metaplasia

VariablesOR (95% CI)P
Age1.01 (0.98–1.03)0.52
H. pylori infection17.0 (3.61–80.12)0.0003
PSCA rs2294008 C/T Genotype2.52 (0.97–6.55)0.059
PSCA rs2294008 T/T Genotype3.04 (1.12–8.26)0.029
Presence of gastric atrophy3.66 (0.94–14.26)0.062
Presence of intestinal metaplasia1.39 (0.72–2.65)0.33
  • NOTE: This analysis was performed in 275 subjects for whom histologic information regarding atrophy and intestinal metaplasia was available. Methylation high, mean z-score methylation > 0.65.