Table 1.

Cancer risk by gene mutation compared with general population (6)

PopulationMLH1 or MSH2MSH6PMS2
CancerriskRiskMean age of onsetRiskMean age of onsetRiskMean age of onset
Colon4.5%52%–82%44–61 years10%–22%54 years15%–20%61–66 years
Endometrium2.7%25%–60%48–62 years16%–26%55 years15%49 years
Ovary1.3%MLH1 – 11%–20% by age 70 years45 years – MLH1MSH6: There are limited data on ovarian cancer risk, with some studies suggesting average risk and some suggesting increased risk.
MSH2 – 15%–24% by age 70 years43 years – MSH1PMS2: There are limited data on ovarian cancer risk.