Table 2.

Effect of various agents on final mammary cancer multiplicity and weight.

AgentMultiplicity (# of cancers/rat)aCancer weight (g)
Control2.584.58
Vorozole0.25 (90% decrease, P = 1e−5)0.36 (92% decrease, P = 6e−5)
Targretin0.20 (92% decrease, P = 6e−6)0.30 (93% decrease, P = 2e−5)
Lipitor2.15 (17% decrease, P = 0.6)5.11 (12% increase, P = 0.7)
Control2.906.79
Naproxen4.20 (45% increase, P = 0.02)10.49 (54% increase, P = 0.05)
Gefitinib0.20 (93% decrease, P = 2e−6)0.14 (98% decrease, P = 1e−6)
Tamoxifen0.00 (100% decrease, P = 1e−9)0.00 (100% decrease, P = 1e−7)
Metformin4.95 (71% increase, P = 0.01)9.71 (43% increase, P = 0.33)
  • aOn the basis of histopathologic analysis following animal sacrifice; P values were calculated using the Mann–Whitney test.