Table 2.

Comparison of studies using circulating EVs to detect ovarian cancer.

Platform usedSelection parametersCase sizeControl sizeAUCSensitivityaSpecificityaReferences
nPLEXEpCAM20100.96890%b100%b95
CD240.90080%b100%b
EpCAM + CD240.99595%b100%b
CD630.67075%b60%b
Microfluidic chip (ExoSearch)EpCAM1551.0093%a100%a98
CA-1251.0093%a100%a
CD240.9193%a80%a
Microfluidic chip (nanoHB)EpCAM20101.00100%a100%a99
CD241.00100%a100%a
FR-α0.99595%a100%a
NTA1.0069%a86%a
  • Note: Pairs of sensitivity and specificity in this table are not directly comparable with each other because they are calculated on the basis of different cutoffs throughout.

  • aSensitivity and specificity pair values listed correspond to a specific decision cutoff utilized in each study. The sensitivity and specificity correspond to the maximized Youden index.

  • bAs reported by each study.