Table 1.

Comparison of epidemiologic risk factors in patients with Barrett's esophagus (n = 587) and population-based controls (n = 1,976).

Barrett cohortPopulation-based control
Characteristicsn (%)n (%)P
Total5871,976
Gender
 Male436 (74.3)948 (48.0)<0.001
 Female151 (25.7)1,028 (52.0)
Age (years)
 Mean (SD)63.4 (12.5)59.3 (12.2)<0.001
 Range23–9338–88
Smoking
 Regular smoker89 (15.2)274 (13.9)<0.001
 Irregular smoker28 (4.8)43 (2.2)
 Ex-smoker251 (42.8)748 (37.9)
 Nonsmoker190 (32.3)911 (46.1)
 Missing29 (4.9)
Alcohol consumption
 <40 g/day386 (65.8)1,742 (88.2)0.006
 >40 g/day77 (13.1)233 (11.8)
 Missing124 (21.1)1 (0.05)
Marital status
 Married386 (65.7)1,451 (73.4)<0.001
 Single85 (14.5)193 (9.8)
 Divorced60 (10.2)166 (8.4)
 Widowed35 (6.0)166 (8.4)
 Missing21 (3.6)
BMI (kg/m2)
 Mean BMI (SD)27.6 (5.4)27.8 (5.1)0.259
 Range16.7–70.616.6–62.2
 Missing252
Physical activity
 Very active146 (24.9)514 (26)0.011
 Moderately active152 (25.9)634 (32.1)
 Little active67 (11.4)284 (14.4)
 Not active189 (32.2)544 (27.5)
 Missing33 (5.6)
Actual state of fitness
 Very good56 (9.5)251 (12.7)<0.001
 Good352 (60.0)1,357 (68.7)
 Intermediate130 (22.1)334 (16.9)
 Poor28 (4.8)34 (1.7)
 Missing21 (3.6)
Relative state of health
 Better177 (30.1)903 (45.7)<0.001
 Equal213 (36.3)889 (45)
 Worse89 (15.2)148 (7.5)
 Unknown87 (14.8)36 (1.8)
 Missing21 (3.6)
GERD symptoms
 Yes359 (61.2)985 (49.8)<0.001
 No199 (33.9)990 (50.1)
 Missing29 (4.9)1 (0.1)
GERD frequency among those answering yes to symptoms
 Frequently177 (49.3)224 (22.7)<0.001
 Occasionally155 (43.2)761 (77.3)
 Unknown27 (7.5)
Reasons for Barrett's esophagus diagnosis
 Dysphagia37 (6.3)
 Reflux238 (40.6)
 Upper abdominal discomfort67 (11.4)
 Incidental finding139 (23.7)
 Other39 (6.6)
 Missing67 (11.4)
Chronic diseases
 Diabetes64 (10.9)169 (8.6)0.097
 Hypertension288 (49.1)957 (48.4)0.824
 Hypercholesterolemia274 (46.7)966 (48.9)0.372
 Neurodermatitis27 (4.6)133 (6.7)0.076
 Asthma52 (8.9)165 (8.4)0.761
 Hay fever92 (15.7)374 (18.9)0.083
  • Note: P values are from Wilcoxon and χ2 tests.