Table 2.

Baseline and 12-month values and change over time for serum levels of systemic hormones.

Median (mean ± SD)P
Biomarker, unitsPlacebo; N = 49SDG; N = 100Mann–Whitney test
Estradiol (pg/mL)
 Baseline79 (132 ± 184)76 (128 ± 205)0.77
 12-month75 (106 ± 99)76 (115 ± 158)0.95
 Change over time1 (−26 ± 121)−4 (−13 ± 72)0.99
 Relative change (%)0 (0 ± 37)−7 (5 ± 46)0.94
 Within group (Wilcoxon test)0.420.24
Estradiol (pmol/L)
 Baseline294 (489 ± 682)281 (475 ± 759)0.77
 12-month279 (392 ± 365)280 (426 ± 583)0.99
 Change over time0 (−96 ± 447)−16 (−49 ± 266)0.99
 Relative change (%)0 (0 ± 37)7 (−5 ± 46)0.92
 Within group (Wilcoxon test)0.370.24
SHBG (nmol/L)
 Baseline69 (98 ± 73)70 (91 ± 65)0.93
 12-month72 (92 ± 61)79 (96 ± 73)0.87
 Change over time−2 (−6 ± 44)1 (5 ± 49)0.31
 Relative change (%)−6 (5 ± 54)1 (9 ± 45)0.36
 Within group (Wilcoxon test)0.370.57
Bioavailable estradiol (pmol/L)
 Baseline3.6 (5.9 ± 9.9)3.2 (5.4 ± 9.2)0.98
 12-month3.0 (4.7 ± 5.3)3.3 (5.0 ± 8.9)0.94
 Change over time0.0 (−1.2 ± 6.5)−0.1 (−0.4 ± 2.5)0.82
 Relative change (%)1 (3 ± 41)−4 (5 ± 50)0.77
 Within group (Wilcoxon test)0.670.33
Progesterone (ng/mL)
 Baseline0.38 (1.85 ± 5.16)0.36 (1.14 ± 2.41)0.78
 12-month0.37 (1.50 ± 4.36)0.43 (1.28 ± 2.59)0.35
 Change over time−0.03 (−0.35 ± 2.47)0.0 (0.14 ± 1.31)0.058
 Relative change (%)−8.5 (23.0 ± 111.4)0.74 (72.5 ± 252.1)0.19
 Within group (Wilcoxon test)0.0830.36