Table 2.

Selected DMRs with inverse DNA methylation change and RNA expression change.

GeneGene nameLocationFeatureDNA methylation change (treatment vs. control)RNA expression log2 fold change (treatment vs. control)
1α25(OH)2D3 (RNA expression increase, methylation decrease)
CYP24A1Cytochrome P450 family 24 subfamily A member 1chr20: 52789045–52789434Promoter−12.211.2
TRPV6Transient receptor potential cation channel subfamily V member 6chr7: 142584106–142584444Promoter−18.37.8
IRS1Insulin receptor substrate 1chr2: 227660036–227660323Promoter−11.74.6
PRRT2Proline rich transmembrane protein 2chr16: 29823628–29824005Promoter−13.34.6
CAMK4Calcium/calmodulin dependent protein kinase IVchr5: 110559299–110559797Promoter−10.74.3
SYNCSyncoilin, intermediate filament proteinchr1: 33169068–33169345Promoter−203.3
RGS17Regulator of G protein signaling 17chr6: 153450993–153451251Promoter−18.43
BAIAP2L2BAI1 associated protein 2 like 2chr22: 38508088–38508248Promoter−15.72.8
EPAS1Endothelial PAS domain protein 1chr2: 46523790–46524036Promoter−16.12.6
DNAH11Dynein axonemal heavy chain 11chr7: 21582584–21582913Promoter−17.72.4
1α25(OH)2D3 (RNA expression decrease, methylation increase)
OBP2BOdorant binding protein 2Bchr9: 136084744–136085168Promoter10.8−8.3
MUC5ACMucin 5AC, oligomeric mucus/gel-formingchr11: 1151319–1151453Promoter30−7.4
FAM3DFamily with sequence similarity 3 member Dchr3: 58653571–58653767Promoter14−5
SLC26A9Solute carrier family 26 member 9chr1: 205909935–205910046Promoter11.6−4.5
NEURL3Neuralized E3 ubiquitin protein ligase 3chr2: 97174131–97174505Promoter11.4−4.3
ZBTB7CZinc finger and BTB domain containing 7Cchr18: 45664078–45664282Promoter10.9−4.3
SMPD3Sphingomyelin phosphodiesterase 3chr16: 68480865–68480956Promoter17−4.1
LFNGLFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferasechr7: 2551215–2551299Promoter17.4−3.9
ANO1Anoctamin 1chr11: 69925157–69925401Promoter12.9−3.5
SYT12Synaptotagmin 12chr11: 66790610–66790701Promoter37.4−3.2
BXL0124 (RNA expression increase, methylation decrease)
CYP24A1Cytochrome P450 family 24 subfamily A member 1chr20: 52788666–52788927Promoter−2012.5
TRPV6Transient receptor potential cation channel subfamily V member 6chr7: 142583185–142583379Promoter−12.58.9
DCNDecorinchr12: 91572142–91572303Promoter−11.96.4
IRS1Insulin receptor substrate 1chr2: 227664786–227665021Promoter−17.45.2
CRISPLD1Cysteine rich secretory protein LCCL domain containing 1chr8: 75896529–75896590Promoter−13.54.3
KLK6Kallikrein related peptidase 6chr19: 51471818–51472142Promoter−13.33.9
SYNCSyncoilin, intermediate filament proteinchr1: 33169068–33169345Promoter−12.73.9
BGLAPBone gamma-Carboxyglutamate proteinchr1: 156211057–156211193Promoter−503.8
GJA1Gap junction protein alpha 1chr6: 121758702–121759148Promoter−12.63.3
PLECPlectinchr8: 145012511–145012576Promoter−15.63.3
1α25(OH)2D3 (RNA expression decrease, methylation increase)
CREB3L1CAMP responsive element binding protein 3 like 1chr11: 46259950–46260255Promoter10.3−9.6
OBP2BOdorant binding protein 2Bchr9: 136084744–136085168Promoter14.5−9.4
BPIFB1BPI fold containing family B member 1chr20: 31871155–31871382Promoter16.7−8.4
SLC26A9Solute carrier family 26 member 9chr1: 205912819–205912892Promoter13−7.7
FAM3DFamily with sequence similarity 3 member Dchr3: 58652298–58652634Promoter11.8−7.1
RARRES3Retinoic acid receptor responder 3chr11: 63304457–63304769Promoter12.6−6.4
CALML5Calmodulin like 5chr10: 5538707–5538846Promoter17.1−5.8
LFNGLFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferasechr7: 2551215–2551299Promoter23.8−5.2
ANO1Anoctamin 1chr11: 69923479–69923824Promoter13.5−5.1
C9orf152Chromosome 9 open reading frame 152chr9: 112970404–112970590Promoter14.3−4.9
  • Note: Genes are arranged in the order of log2 change. Gene names are taken from www.genecards.org.