Table 1.

Top 25 most upregulated and downregulated genes in comparison with 1α25(OH)2D3 versus control and BXL0124 versus control.

1α25(OH)2D3BXL0124
Upregulated geneGene nameLog2 fold changeZ-scoreLog2 fold changeZ-score
CYP24A1Cytochrome P450 family 24 subfamily A member 110.3205.811.3268.3
IGFL3IGF like family member 38.513.810.423.7
TRPV6Transient receptor potential cation channel subfamily V member 67.5108.98.5148.1
CYTH4Cytohesin 47.017.97.822.8
GIMAP8GTPase, IMAP family member 86.98.68.513.9
OPCMLOpioid binding protein/cell adhesion molecule like6.37.26.98.5
RP1Retinitis pigmentosa 16.314.07.420.3
ABCD2ATP binding cassette subfamily D member 26.16.56.57.6
GNRHRGonadotropin releasing hormone receptor6.16.56.26.8
CNGB1Cyclic nucleotide gated channel beta 16.06.47.29.3
CSNK1ECasein kinase 1 epsilon5.98.64.55.2
ZEB2Zinc finger E-Box binding homeobox 25.78.25.26.7
ZNF699Zinc finger protein 6995.75.86.37.1
IGFL1IGF like family member 15.75.76.16.6
DCNDecorin5.611.06.113.1
GTF2IP4General transcription factor IIi pseudogene 45.65.55.14.7
MT4Metallothionein 45.57.43.83.9
NPTN-IT1NPTN intronic transcript 15.34.96.57.5
KRT24Keratin 245.29.75.29.6
SHESrc homology 2 domain containing E5.26.87.012.6
SLC7A8Solute carrier family 7 member 85.19.45.510.9
PGLYRP3Peptidoglycan recognition protein 35.16.64.55.3
CYP2C18Cytochrome P450 family 2 subfamily C member 185.14.66.47.3
LINC00504Long intergenic non-protein coding RNA 5045.14.66.26.8
CT62Cancer/testis antigen 625.16.54.55.2
1α25(OH)2D3BXL0124
Downregulated geneGene nameLog2 fold changeZ-scoreLog2 fold changeZ-score
LACRTLacritin−9.9−17.8−9.9−17.8
CREB3L1CAMP responsive element binding protein 3 like 1−9.8−69.6−9.5−71.4
FCGBPFc fragment of IgG binding protein−9.6−99.3−9.2−102.4
SLC44A4Solute carrier family 44 member 4−9.3−15.0−6.3−17.2
HMGCS23-Hydroxy-3-Methylglutaryl-CoA synthase 2−9.0−27.8−8.0−29.5
BPIFA1BPI fold containing family A member 1−8.7−12.6−6.7−13.8
DCDDermcidin−8.6−24.6−8.6−24.7
LEFTY1Left-right determination factor 1−8.6−12.2−5.6−13.4
IQGAP2IQ motif containing GTPase activating protein 2−8.3−11.4−8.3−11.4
OBP2BOdorant binding protein 2B−8.2−34.7−9.5−32.1
PIGRPolymeric immunoglobulin receptor−8.1−10.8−8.2−10.8
CYP4Z2PCytochrome P450 family 4 subfamily Z member 2, pseudogene−8.0−10.3−8.0−10.3
GJB1Gap junction protein beta 1−8.0−10.2−6.0−10.9
THRSPThyroid hormone responsive−7.9−10.2−5.0−10.7
CRYMCrystallin Mu−7.9−14.1−4.6−14.5
MUC5ACMucin 5AC, oligomeric mucus/gel-forming−7.6−53.6−8.1−52.5
CHRM1Cholinergic receptor muscarinic 1−7.5−8.8−7.5−8.8
CLDN10Claudin 10−7.3−35.1−8.5−33.4
MS4A7Membrane spanning 4-domains A7−7.2−8.1−7.2−8.2
UGT2B11UDP glucuronosyltransferase family 2 member B11−7.1−7.8−7.1−7.8
RPRMLReprimo like−6.9−7.4−6.9−7.5
ATP2A3ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3−6.6−28.9−10.8−22.9
BPIFB1BPI fold containing family B member 1−6.6−64.7−8.2−61.4
SPINK8Serine peptidase inhibitor, Kazal type 8−6.6−6.7−6.6−6.7
LOC101927822RNA gene−6.6−6.6−6.6−6.6
  • Note: Genes are arranged in the order of log2 change. Gene names are taken from www.genecards.org.