ORs for cancer risk for all ATM PVs.
| All ATM PVs | ||
|---|---|---|
| Cancer type | OR (95% CI) | P |
| Breast - Ductal Invasive | 2.03 (1.89–2.19) | <0.0001 |
| Breast - DCIS | 1.80 (1.61–2.02) | <0.0001 |
| Breast – Lobular Invasive | 0.94 (0.74–1.20) | 0.6229 |
| Breast - Male | 1.72 (1.08–2.75) | 0.0233 |
| Ovarian | 1.57 (1.35–1.83) | <0.0001 |
| Colorectal | 1.49 (1.24–1.79) | <0.0001 |
| Endometrial | 1.10 (0.88–1.36) | 0.4079 |
| Melanoma | 1.46 (1.18–1.81) | 0.0006 |
| Prostate | 2.58 (1.93–3.44) | <0.0001 |
| Pancreatic | 4.21 (3.24–5.47) | <0.0001 |
| Gastric | 2.97 (1.66–5.31) | 0.0002 |
Note: ORs are adjusted for personal (coded as binary, affected/unaffected, variables) and family (numeric counts weighted by degree of relation) cancer histories of breast (invasive, ductal, DCIS, and male), ovarian, colorectal, melanoma, gastric, pancreatic, prostate, endometrial, and colon (polyps), as well as age, sex, and ancestry.