Table 1.

Demographics and personal cancer history by ATM PV carrier status.

ATM PVNo ATM PVaTotal
Characteristic(N = 4,607)(N = 623,135)(N = 627,742)
Age at testing - median (IQR)49 (39, 59)48 (38, 58)48 (38, 58)
Sex
 Female4,378 (95.0)601,246 (96.5)605,624 (96.5)
 Male229 (5.0)21,889 (3.5)22,118 (3.5)
Race/Ethnicity
 White/Caucasian2,889 (62.9)358,097 (57.5)360,996 (57.5)
 Black/African289 (6.3)51,324 (8.2)51,613 (8.2)
 Latino/Hispanic288 (6.3)46,713 (7.5)47,001 (7.5)
 Asian100 (2.2)14,224 (2.3)14,324 (2.3)
 Ashkenazi Jewish34 (0.7)10,302 (1.7)10,336 (1.6)
 Native American31 (0.7)5,141 (0.8)5,172 (0.8)
 Middle Eastern21 (0.5)3,428 (0.6)3,449 (0.5)
 Multiple270 (5.9)41,021 (6.6)41,291 (6.6)
 Other/None specified675 (14.7)92,885 (14.9)93,560 (14.9)
Personal cancer history
Total cancers
 0 cancer2,243 (48.7)385,932 (61.9)388,175 (61.8)
 1 cancer1,928 (41.8)203,668 (32.7)205,596 (32.8)
 2+ cancers436 (9.5)33,535 (5.4)33,971 (5.4)
Any Cancer2,364 (51.3)237,203 (38.1)239,567 (38.2)
Breast – Ductal Invasiveb1,461 (33.4)132,465 (22.0)133,926 (22.1)
Breast – Triple-negativeb52 (1.2)19,711 (3.3)19,763 (3.3)
Breast – Lobular Invasiveb68 (1.6)10,633 (1.8)10,701 (1.8)
Breast - DCISb351 (8.0)28,906 (4.8)29,257 (4.8)
Breast - Malec20 (8.7)1,909 (8.7)1,929 (8.7)
Ovarian cancerb192 (4.4)24,616 (4.1)24,808 (4.1)
Colorectal cancer135 (2.9)14,527 (2.3)14,662 (2.3)
Endometrial cancerb85 (1.9)11,877 (2.0)11,962 (2.0)
Melanoma88 (1.9)7,426 (1.2)7,514 (1.2)
Prostate cancerc75 (32.8)4,436 (20.3)4,511 (20.4)
Pancreatic cancer64 (1.4)2,085 (0.3)2,149 (0.3)
Gastric cancer12 (0.3)518 (0.1)530 (0.1)
  • aPatients with no PVs in any gene tested, including ATM, and no VUS in ATM.

  • bFemale only.

  • cMale only.

  • Triple-negative breast cancer is a subset of ductal invasive for this cohort. All other categories are exclusive.