Table 2.

Test performance in the evaluable cohort.

mt-sDNA (N = 816)
Most advanced findingColonoscopy (N = 816) no.Positive Results, no.Specificity, % (95% CI)
All nonadvanced adenomas, non-neoplastic findings, and negative results on colonoscopy7673795.2 (93.4–96.6)
Negative results on colonoscopy5141996.3 (94.3–97.8)
Prevalence, % (N = 816)Sensitivity, % (95% CI)
Colorectal cancer0NANANA
Advanced precancerous lesionsa496.01632.7 (19.9–47.5)
 High-grade dysplasia0<0.1NANA
 Adenoma, villous growth pattern101.2660.0 (26.2–87.8)
 Adenoma ≥10 mm323.9728.1 (13.7–46.7)
 Serrated lesion ≥10 mm70.9114.3 (0.4–57.9)
Nonadvanced adenoma25331.0187.1 (4.3–11.0)
  • Abbreviations: NA, not applicable; no., number.

  • aOn the basis of most advanced lesion; therefore, prevalence estimates for less advanced lesions are biased downward.