Table 4.

Biomarker change at 6 months by four groups defined by randomization arm (placebo vs. ω-3 FA) and dichotomization by weight loss (<10% or >10%).

Median relative change and associated P value for change over time
<10% weight loss<10% weight loss>10% weight loss>10% weight loss
Placeboω-3 FAPlaceboω-3 FA
Biomarker or ratioGroup 1 N = 11Group 2 N = 10Group 3 N = 11Group 4 N = 10
Adiponectin2%0.3311%0.2419%0.2930%0.037
Leptin−26%0.022−16%0.0069−78%0.0050−65%0.0051
Adiponectin:Leptin ratio35%0.01663%0.017390%0.0051264%0.0051
Lipocalin-213%0.18−3%0.65−8%0.51−34%0.0093
Resistin−6%0.86−6%0.39−8%0.33−17%0.017
PAI-1−6%0.66−10%0.037−13%0.028−16%0.022
HGF−0%0.931%0.88−17%0.028−20%0.0093
Omentin−10%0.337%0.2819%0.4811%0.041
CRP−11%0.59−14%0.51−6%0.48−52%0.0069
TNFα−2%0.330%0.67−13%0.57−4%0.032
SHBG10%0.05127%0.01326%0.004468%0.0051
Bioavailable estradiol−11%0.133%0.81−14%0.26−29%0.032
Bioavailable testosterone−13%0.42−5%0.14−28%0.29−47%0.017
Insulin−14%0.42−20%0.58−51%0.047−61%0.0051
Number modulated24614
  • Note: Biomarkers are grouped into categories of adipokines, cytokines, hormones/growth factors, and insulin. A total of 25 biomarkers or ratios were assessed. There is no adjustment for multiple comparisons so caution is advised in interpretation of the results.

  • Wilcoxon nonparametric signed-rank test, two-tailed, for within-group differences between baseline and 6 months.