Table 2.

Weight change during 12-month progestin treatment window.

Bariatric surgeryLow-calorie dietAll participants
(n = 22)(n = 44)(n = 66)a
Mean weight (SD), kgBaseline137.7 (19.1)118.8 (23.4)125.1 (23.7)
12 months104.3 (17.1)114.2 (21.9)110.9 (20.8)
Mean difference (95% CI), 12 months vs. baseline−33.4 (−42.1 to −24.7)−4.6 (−7.8 to −1.4)−14.2 (−19.0 to −9.4)
P < 0.001P = 0.005P < 0.001
Mean BMI (SD), kg/m2Baseline51.9 (7.5)45.1 (9.0)47.3 (9.0)
12 months39.1 (5.5)43.4 (8.5)41.9 (7.8)
Mean difference (95% CI), 12 months vs. baseline−12.8 (−16.2 to −9.5)−1.7 (−2.9 to −0.5)−5.4 (−8.3 to −2.5)
P < 0.001P = 0.006P < 0.001
Mean change in total body weight (SD), % 12 months vs. baseline−23.6 (13.0)−3.4 (8.0)−10.2 (13.7)
Mean change in total body weight at 12 months, bariatric surgery vs. low-calorie dietP < 0.001
Mean change in BMI (SD), kg/m2 12 months vs. baseline−12.8 (7.5)−1.7 (4.0)−5.4 (7.5)
Mean change in BMI at 12 months, bariatric surgery vs. low-calorie dietP < 0.001
Weight loss >10% total body weight, n (%)19 (86)10 (23)29 (44)
Proportion of women losing >10% total body weight at 12 months, bariatric surgery vs. low-calorie dietP < 0.001
  • a12-month assessments are not included for the n = 5 women who progressed during progestin treatment, whose mean weight loss at progression was −6.4 kg (95% CI −18.2, −1.0); 1 had lost >10% of their total body weight.